Similarities and Differences: Signaling Mechanisms Induced by Contact Sensitizers
نویسندگان
چکیده
منابع مشابه
Similarities and differences in inflammatory mechanisms of asthma and COPD
Asthma and chronic obstructive pulmonary disease (COPD) are both characterised by airway obstruction, which is variable and reversible in asthma but is progressive and largely irreversible in COPD. In both diseases, there is chronic inflammation of the respiratory tract, which is mediated by the increased expression of multiple inflammatory proteins, including cytokines, chemokines, adhesion mo...
متن کاملDynamics matter: differences and similarities between alternatively designed mechanisms.
Cells selectively respond to external stimuli to maintain cellular homeostasis by making use of different regulatory mechanisms. We studied two classes of signal-dependent regulatory inhibition and activation mechanisms in this study. Inhibition mechanisms assume that inhibition can occur in two different ways: either by increasing the degradation rate or decreasing the production rate. Similar...
متن کاملMolecular events associated with dendritic cells activation by contact sensitizers.
Dendritic cells are unique heterogenous cell population capable of responding to different inflammatory signals. These signals induce the process of maturation forcing cells to leave the inflamed site and to migrate to draining lymph nodes. During this process, dendritic cells have to initiate differentiation responses expressed among others by up-regulation of some surface antigens (e.g., MHC ...
متن کاملNiches: Similarities and Differences
Organisms are machines designed by their evolution to play a certain role. This role, together with the environment within which it is played, is called the organism's niche 1. For example, most cats — tigers, leopards, mountain lions — play the role of solitary hunters; wolves and wild dogs are social hunters; antelope are social grazers; and so on. The niche defines the patterns of adaptive b...
متن کاملIn vitro differentiation of skin sensitizers by cell signaling pathways.
Animal testing causes ethical problems and in view of EU regulations (e.g. EU-Guideline (76/768/EEC, February 2003)) or REACH the development of reliable in vitro assays has become even more important. Up to now, we use the modified local lymph node assay (IMDS) for toxicological hazard identification of sensitizing and irritant properties of chemicals in accordance with OECD Guideline 429. In ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2003
ISSN: 0022-202X
DOI: 10.1046/j.1523-1747.2003.12108.x